Publications

Selected articles from CoE members

2021

  • Moreno-Layseca P, Jäntti NZ, Godbole R, Sommer C, Jacquemet G, Al-Akhrass H, Conway JRW, Kronqvist P, Kallionpää RE,  Oliveira-Ferrer L, Cervero P, Linder S, Aepfelbacher M, Zauber H, Rae J, Parton RG, Disanza A, Scita G, Mayor S,  Selbach M, Veltel S & Ivaska J (2021) Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis. Nat. Cell Biol.  23, pages1073–1084 – Share link, Open access here!
  • Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickström SA. (2021) Niche stiffening compromises stem cell potential during aging by reducing chromatin accessibility at bivalent promoters. Nat Cell Biol 7, 771-781.
  • Salomaa SI, Miihkinen M, Kremneva E, Ilkka Paatero I, Lilja J, Jacquemet G, Vuorio J, Antenucci L, Kogan K, Nia FH, Hollos P, Isomursu A, Vattulainen I, Coffey ET, Kreienkamp H-J, Lappalainen P and Ivaska J (2021) SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling. Current Biology S0960-9822(21)01262-8 PMID: 34610274
  • Lehtimäki JI, Rajakylä EK, Tojkander S, Lappalainen P. Generation of stress fibers through myosin-driven re-organization of the actin cortex (2021). eLife 10:e60710. doi: 10.7554/eLife.60710
  • Hakala M, Wioland H, Tolonen M, Kotila T, Jegou A, Romet-Lemonne G, Lappalainen P (2021). Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks. Nature Cell Biol. 23: 147-159. doi: 10.1038/s41556-020-00629-y
  • Miihkinen M, Grönloh MLB, Popovic A, Vihinen H, Eija Jokitalo E, Goult BT, Ivaska J and Jacquemet G (2021) Myosin-X and talin modulate integrin activity at filopodia tips. Cell Report. vol 36, Issue 11, 109716. PMID: 34525374
  • Casarotto, P.C., Girych, M., Fred, S.M., Kovaleva, V., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Sahu, M.P., Kaurinkoski, K., Brunello, C.A., Steinzeig, A., Winkel, F., Patil, S., Vestring, S., Serchov, T., Diniz, C.R.A.F., Laukkanen, L., Cardon, I., Antila, H., Róg, T., Piepponen, T.P., Bramham, C.R., Normann, C., Lauri, S.E., Saarma, M., Vattulainen, I., and Castrén, E (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184, 1299-1313.e19. DOI: https://doi.org/10.1016/j.cell.2021.01.034

2020

  • Kim CS, Ding X, Allmeroth K, Biggs, LC, Kolenc OI, L’Hoest N, Chacón-Martínez CA, Edlich-Muth C, Giavalisco P, Quinn KP, Denzel M, Eming SA, Wickström SA. (2020) Glutamine metabolism controls stem cell fate reversibility and long-term maintenance in the hair follicle. Cell Metabolism 32, 629-642.e8
  • Dekoninck S, Hannezo E, Sifrim A, Miroshnikova YA, Aragona M, Malfait M, Gargouri S, de Neunheuser C, Dubois C, Voet T, Wickström SA, Simons BD, Blanpain C. (2020) Defining the Design Principles of Skin Epidermis Postnatal Growth.Cell 181, 604-620
  • Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffman B, Merkel R, Niessen CM, Dahl KN, Wickström SA. (2020) Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell 181, 800-817
  • Wilmes, S., Hafer, M., Vuorio, J., Tucker, J.A., Winkelmann, H., Lochte, S., Stanly, T.A., Pulgar Prieto, K.D., Poojari, Ch., Sharma, V., Richter, Ch.P., Kurre, R., Hubbard, S.R., Garcia, K.Ch., Moraga, I., Vattulainen, I., Hitchcock, I.S., and Piehler, J (2020) Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science,367, 643-652 (2020). DOI: https://doi.org/10.1126/science.aaw3242

2019

  • Kotila T, Wioland H, Enkavi G, Kogan K, Vattulainen I, Jégou A, Romet-Lemonne G, Lappalainen P (2019) Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin. Nature Commun. 10:5320. doi: 10.1038/s41467-019-13213-2
  • Stubb A, Guzmán C, Närvä E, Aaron J, Chew TL, Saari M, Miihkinen M, Jacquemet G, Ivaska J (2019) Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells. Nat Commun. 10(1):4756. PMID:31628312
  • Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, Ivaska J (2019) Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability. Curr Biol. 29, 1–15.  Link to article
  • Kumari R, Jiu Y, Carman PJ, Tojkander S. Kogan K, Varjosalo M, Gunning PW, Dominguez R, Lappalainen P. Tropomodulins control the balance between protrusive and contractile structures by stabilizing actin-tropomyosin filaments. Curr. Biol. 30: 767–778. doi: 10.1016/j.cub.2019.12.049.

2018

  • Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Höppner N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA. (2018). Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.Nat Cell Biol20, 69-80. Highlighted by Faculty of 1000
  • Hakanpaa L, Kiss EA, Jacquemet G, Miinalainen I, Lerche M, Guzmán C, Mervaala E, Eklund L, Ivaska J, Saharinen P ( 2018) Targeting β1-integrin inhibits vascular leakage in endotoxemia. Proc Natl Acad Sci (U S A). 115:E6467-E6476
  • *Kotila T, *Kogan K, Enkavi G, Guo S, Vattulainen I, Goode BL, Lappalainen P. Structural basis of actin monomer re-charging by cyclase-associated protein. Nature Commun. 9:1892. doi: 10.1038/s41467-018-04231-7.*equal contribution.

2017

  • Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J (2017) SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nat Cell Biol 19(4):292-305. PMID: 28263956
  • Saharinen P, Eklund L, Alitalo K (2017) Therapeutic targeting of the angiopoietin-Tie pathway. Nat Rev Drug Disc. 16:635-661
  • Senju Y, Kalimeri M, Koskela EV, Somerharju P, Zhao H, Vattulainen I, Lappalainen P (2017) Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides. Proc. Natl. Acad. Sci. 114: E8977-E8986. doi:10.1073/pnas.1705032114
  • Gateva G, Kremneva E, Reindl T, Kotila T, Kogan K, Gressin L, Gunning PW, Manstein DJ, Michelot A, Lappalainen P. Tropomyosin isoforms specify functionally distinct actin filament populations in vitro. Curr. Biol. 27, 705-713. doi:10.1016/j.cub.2017.01.018.

2015 -2016

  • Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J (2016) Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.Nat Commun 7:12237. PMID: 27488962
  • Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. NatCell Biol 18, 864-875. Highlighted by Nature Reviews Molecular Cell Biology, Faculty of 1000
  • Korhonen E*, Lampinen A*, Giri H, Anisimov A, Kim M, Allen B, Fang S, D’Amico G, Sipila T, Lohela M, Strandin T, Vaheri, Ylä-Herttuala S, Koh GY, McDonald DM, #Alitalo K and # Saharinen P (2016) Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest. 126: 3495-3510. *#equal
  • Manna, M., Niemela, M., Tynkkynen, J., Javanainen, M., Kulig, W., Muller, D. J., Rog, T. and Vattulainen, I. Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol. eLife 5 18432 (2016). DOI: http://dx.doi.org/10.7554/eLife.18432
  • Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P. (2015) Endothelial destabilization by angiopoietin-2 via integrin 1 activation. Nature Commun. 6:5962

Tojkander S, Gateva G, Husain A, Krishnan R, Lappalainen P. Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly. eLife, 4:e06126. doi:10.7554/eLife.06126.

Jiu Y, Lehtimäki J, Tojkander S, Cheng F, Jäälinoja H, Liu X, Varjosalo M, Eriksson JE, Lappalainen P. Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers. Cell Reports 11: 1511-1518. doi:10.1016/j.celrep.2015.05.008.