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Barrier Force

Signal Integration and Forces – from Molecular-Scale to Tissue-Level Understanding

About BarrierForce

BarrierForce is a Research Council of Finland Centre of Excellence (CoE; 2022 – 2029). We combine expertise from five different groups, based in Turku and Helsinki, to understand how tissue barriers formed by endothelial, epithelial and keratinocyte cell layers perform their protective roles and how these are disrupted in disease. We aim to provide a comprehensive overview of barrier physiology and pathology across different scales (molecules – cells – tissues) with the ultimate goal of finding therapeutic strategies.

PROJECTS

BarrierForce CoE aims to gain fundamental new knowledge of molecular and cellular organ-specific barriers across the scales to address global health problems.

Recent Publications from Barrier Force

Thursday, August 21, 2025 CoE-publications
Mitochondria have a crucial role in regulating cellular homeostasis in response to...
Friday, August 15, 2025 CoE-publications
Formation of the skin barrier is essential for organismal survival and tissue home...
Tuesday, July 08, 2025 CoE-publications
Integrin β1-mediated adhesion is dispensable in early mouse embryogenesis (pre-imp...
Friday, July 04, 2025 CoE-publications
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been de...
Wednesday, May 28, 2025 CoE-publications
Lymphatic capillaries continuously take up interstitial fluid and adapt to resulti...
Monday, May 26, 2025 CoE-publications
Integrins provide an essential bridge between cancer cells and the extracellular m...
Wednesday, April 02, 2025 CoE-publications
Tissue deformations are a central feature of development, from early embryogenesis...
Monday, October 28, 2024 CoE-publications
Epithelial tumors are characterized by abundant inter- and intra-tumor heterogenei...
Monday, September 30, 2024 CoE-publications
Integrin receptors are the main molecular link between cells and the extracellular...
Thursday, September 12, 2024 CoE-publications
The KRAS oncogene drives many common and highly fatal malignancies. These include ...
Saturday, September 07, 2024 CoE-publications
Acquisition of specific cell shapes and morphologies is a central component of cel...
Monday, September 02, 2024 CoE-publications
We previously identified talin rod domain-containing protein 1 (TLNRD1) as a poten...