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Barrier Force

Signal Integration and Forces – from Molecular-Scale to Tissue-Level Understanding

About BarrierForce

BarrierForce is a Research Council of Finland Centre of Excellence (CoE; 2022 – 2029). We combine expertise from five different groups, based in Turku and Helsinki, to understand how tissue barriers formed by endothelial, epithelial and keratinocyte cell layers perform their protective roles and how these are disrupted in disease. We aim to provide a comprehensive overview of barrier physiology and pathology across different scales (molecules – cells – tissues) with the ultimate goal of finding therapeutic strategies.

PROJECTS

BarrierForce CoE aims to gain fundamental new knowledge of molecular and cellular organ-specific barriers across the scales to address global health problems.

Recent Publications from Barrier Force

Monday, October 28, 2024 CoE-publications
Epithelial tumors are characterized by abundant inter- and intra-tumor heterogenei...
Monday, September 30, 2024 CoE-publications
Integrin receptors are the main molecular link between cells and the extracellular...
Thursday, September 12, 2024 CoE-publications
The KRAS oncogene drives many common and highly fatal malignancies. These include ...
Saturday, September 07, 2024 CoE-publications
Acquisition of specific cell shapes and morphologies is a central component of cel...
Monday, September 02, 2024 CoE-publications
We previously identified talin rod domain-containing protein 1 (TLNRD1) as a poten...
Tuesday, August 20, 2024 CoE-publications
Increased extracellular matrix (ECM) and matrix stiffness promote solid tumor prog...
Tuesday, July 23, 2024 CoE-publications
The Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein ...
Monday, June 17, 2024 CoE-publications
While organ-confined prostate cancer (PCa) is mostly therapeutically manageable, m...
Friday, May 24, 2024 CoE-publications
Background: Preclinical studies have shown the therapeutic potential of VEGF-B (...
Wednesday, May 01, 2024 CoE-publications
Carrageenans are industrially important polysaccharides with tunable viscoelastic ...
Saturday, April 27, 2024 CoE-publications
The escalation of global plastic production, reaching an annual output of 400 mill...
Tuesday, April 16, 2024 CoE-publications
Integrin-mediated cell adhesion is essential for cell migration, mechanotransducti...