About BarrierForce
BarrierForce is a Research Council of Finland Centre of Excellence (CoE; 2022 – 2029). We combine expertise from five different groups, based in Turku and Helsinki, to understand how tissue barriers formed by endothelial, epithelial and keratinocyte cell layers perform their protective roles and how these are disrupted in disease. We aim to provide a comprehensive overview of barrier physiology and pathology across different scales (molecules – cells – tissues) with the ultimate goal of finding therapeutic strategies.
Projects
BarrierForce CoE aims to gain fundamental new knowledge of molecular and cellular organ-specific barriers across the scales to address global health problems.
- WP1 Molecule/s: fundamental barrier building blocks
- WP2 Cells, tissues, organs: the organ specific barriers
- WP3 Organisms: in vivo organ-specific barriers
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Work package 1
To gain knowledge of protein structures, molecular mechanisms and adhesion dynamics important in barrier maintenance. Expertise from:
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Work package 2
To understand tissue architecture during perturbations and disease. Expertise from:
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Work package 3
To discover how barriers are built, maintained and disrupted. Expertise from:
